Of course is an informal way of saying 'yes' or to give someone permission to do something.
For example:-
Student: Can I have some extra homework?
Me: Of course you can.
Off course is used when a vehicle doesn't follow a planned, or intended, route.
For example:-
Tapes recovered from the airliner's cockpit voice recorder indicate that the crew were unaware that they were off course and violating Soviet airspace.
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